Penny Clarke Selected Research

Reoviridae Infections

1/2019	Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis.
1/2019	Interferon Beta Contributes to Astrocyte Activation in the Brain following Reovirus Infection.
1/2016	Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis.
3/2013	Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis.
8/2012	Activation of innate immune responses in the central nervous system during reovirus myelitis.
7/2007	Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase.
1/2007	Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis.
5/2003	Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Penny Clarke Research Topics

Disease

16	Infections 09/2023 - 05/2003
8	Reoviridae Infections 01/2019 - 05/2003
7	Encephalitis (Encephalitis, Rasmussen) 01/2023 - 07/2007
6	West Nile Fever 01/2023 - 01/2014
6	Virus Diseases (Viral Diseases) 01/2023 - 07/2007
5	Neuroinflammatory Diseases 01/2021 - 11/2014
4	Paralysis (Palsy) 01/2023 - 01/2017
3	Central Nervous System Diseases (CNS Diseases) 01/2021 - 03/2014
3	Viral Encephalitis 01/2019 - 07/2007
2	COVID-19 09/2023 - 01/2020
2	acute flaccid myelitis 01/2023 - 01/2022
2	Inflammation (Inflammations) 01/2020 - 03/2014
2	Myelitis 01/2017 - 08/2012
2	Neoplasms (Cancer) 01/2016 - 01/2002
2	Central Nervous System Infections (Central Nervous System Infection) 11/2014 - 07/2007
1	Learning Disabilities (Learning Disability) 09/2023
1	Autistic Disorder (Autism) 09/2023
1	Viremia 01/2023
1	Leukopenia 01/2023
1	Neurologic Manifestations (Neurological Manifestations) 01/2022
1	Pneumonia (Pneumonitis) 01/2020
1	Viral Pneumonia 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2020
1	Down Syndrome (Down's Syndrome) 01/2020
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2020
1	Gliosis 01/2019
1	Brain Edema (Cerebral Edema) 01/2019
1	Myocarditis (Carditis) 11/2010
1	Gestational Diabetes (Gestational Diabetes Mellitus) 08/2005
1	Carcinoma (Carcinomatosis) 01/2002

Drug/Important Bio-Agent (IBA)

6	CytokinesIBA 01/2023 - 02/2010
5	Antiviral Agents (Antivirals)IBA 01/2023 - 03/2013
4	Caspase 3 (Caspase-3)IBA 01/2019 - 07/2007
3	InterferonsIBA 01/2019 - 08/2012
3	Proteins (Proteins, Gene)FDA Link 11/2017 - 08/2012
3	CaspasesIBA 01/2014 - 01/2007
3	Caspase 8 (Caspase-8)IBA 01/2014 - 06/2009
3	Death Domain ReceptorsIBA 01/2014 - 01/2002
2	VaccinesIBA 01/2023 - 01/2021
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2023 - 01/2020
2	Neutralizing AntibodiesIBA 01/2022 - 12/2017
2	ChemokinesIBA 01/2022 - 11/2014
2	Minocycline (Cyclops)FDA LinkGeneric 11/2017 - 11/2014
2	Caspase 9IBA 01/2014 - 11/2010
2	JNK Mitogen-Activated Protein KinasesIBA 06/2009 - 07/2007
2	NF-kappa B (NF-kB)IBA 05/2003 - 01/2002
1	sargramostim (Leukine)FDA Link 01/2023
1	telaprevirIBA 01/2023
1	Monoclonal AntibodiesIBA 01/2022
1	PLX5622IBA 01/2022
1	Rosiglitazone (Avandia)FDA Link 01/2021
1	PPAR gammaIBA 01/2021
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2019
1	Interferon-gamma (Interferon, gamma)IBA 01/2019
1	Glial Fibrillary Acidic ProteinIBA 01/2019
1	Oxygen (Dioxygen)IBA 01/2019
1	RNA (Ribonucleic Acid)IBA 01/2019
1	Interferon-betaIBA 01/2019
1	rho-Associated KinasesIBA 01/2019
1	Dexamethasone (Maxidex)FDA LinkGeneric 12/2017
1	HIV hyperimmune globulinIBA 12/2017
1	Fluoxetine (Prozac)FDA LinkGeneric 12/2017
1	Intravenous Immunoglobulins (IVIG)FDA Link 12/2017
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 11/2017
1	Immune Sera (Antisera)IBA 01/2017
1	pifithrinIBA 01/2016
1	Interleukin-6 (Interleukin 6)IBA 11/2014
1	Glutamic Acid (Glutamate)FDA Link 03/2014
1	Interferon Type IIBA 08/2011
1	Messenger RNA (mRNA)IBA 06/2009
1	AntigensIBA 06/2009
1	CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA 01/2007
1	Blood Glucose (Blood Sugar)IBA 08/2005
1	OligonucleotidesIBA 08/2003
1	Ribavirin (Virazole)FDA LinkGeneric 05/2003
1	Member 10c Tumor Necrosis Factor ReceptorsIBA 01/2002
1	Apoptosis Regulatory ProteinsIBA 01/2002
1	MutagensIBA 01/2002
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2002
1	Etoposide (VP 16)FDA LinkGeneric 01/2002

Therapy/Procedure

9	Therapeutics 01/2023 - 07/2007
3	Drug Therapy (Chemotherapy) 01/2023 - 01/2002
1	Critical Care (Surgical Intensive Care) 09/2023
1	Aftercare (After-Treatment) 01/2023
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2023